Keeping your BUN levels in the normal range depends on the underlying cause of the abnormal BUN levels and may require following appropriate lifestyle changes, taking prescribed medicines and eating a healthy and well-balanced diet. It is quite possible to get normal BUN levels after episodes of decreased or increased BUN levels. Pregnancy (the reason is increased plasma volume.).Drinking a lot of water or overhydration.Anabolic steroids as they decrease the breakdown of proteins.Growth hormone deficient children who receive human growth hormone have decreased levels of BUN. Genetic deficiency of the enzymes of the urea cycle.Impaired activity of the liver due to disease of the liver.A diet low in protein, starvation or malnutrition.Kidney failure or disease and urinary tract blockage by a kidney stone. Glucocorticoids, tetracyclines and other antianabolic drugs.Abnormalities of the thyroid gland, which leads to abnormal functioning of the kidneys.Poor circulation, which leads to decreased blood flow to the kidneys, thereby decreasing their ability to filter urea nitrogen.This protein is then metabolized to BUN by the liver. When bleeding from upper GI tract occurs, that blood is digested to form protein. Protein breakdown is also increased by cortisol hormone, thereby elevating BUN levels. BUN is elevated when activation of sympathetic arginine-vasopressin and angiotensin-aldosterone systems is inappropriately increased. BUN levels are increased as blood volume is decreased.
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